Bookcover of TIA-1 and Herpes Simplex Virus Type 1: An Interaction
Booktitle:

TIA-1 and Herpes Simplex Virus Type 1: An Interaction

The Influence of TIA-1 on HSV-1 Replication

VDM Verlag Dr. Müller (2008-10-29 )

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ISBN-13:

978-3-639-08842-7

ISBN-10:
3639088425
EAN:
9783639088427
Book language:
English
Blurb/Shorttext:
During the process of protein translation, phosphorylation of eIF2-alpha prevents its binding to the preinitiation complex and hence the process of translation. The RNA binding protein, TIA-1, then directs these complexes to molecular storage depots known as stress granules. The replication of HSV-1, containing different variants of the ICP34.5 gene and those without the ICP34.5 gene were compared in diploid fibroblasts obtained from normal mice, those lacking TIA-1 and reconstituted with TIA-1. This research showed that HSV-1 replicates better in cells that lack TIA-1. The extent of viral replication was strain dependent. This shows that the cell has a method for preventing viral replication. The functions of TIA-1 include the formation of stress granules in cells which undergo abortive protein translation and cytokine modulation. This study explores the possibility of interaction of the cellular protein, TIA-1 at the viral replication level. The possibility may be that TIA-1 affects, in a strain dependent manner, replication of HSV-1. A potential mechanism for antiviral properties of the cellular protein TIA-1 is be discussed.
Publishing house:
VDM Verlag Dr. Müller
Website:
http://www.vdm-verlag.de/
By (author) :
William Stewart
Number of pages:
64
Published on:
2008-10-29
Stock:
Available
Category:
Microbiology
Price:
4804.51 руб
Keywords:
Leadership, Management, Military, q-methodology, Organizational Theory and Culture, TIA-1, ICP34.5, Stress Granules, Herpes Virus, Protein translation

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