Bookcover of Thioorganic−Boronic Acid Desulfitative Coupling
Booktitle:

Thioorganic−Boronic Acid Desulfitative Coupling

A Desulfitative Strategy to Synthesize Peptidyl Ketone in High Enantiopurity and Application to Total Synthesis of Natural Products

LAP LAMBERT Academic Publishing (2009-09-15 )

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ISBN-13:

978-3-8383-1551-5

ISBN-10:
3838315510
EAN:
9783838315515
Book language:
English
Blurb/Shorttext:
A background of desulfitative cross coupling of thioorganic compounds and boronic acids is well introduced in chapter 1. Desulfitative cross coupling reactions are successfully applied to synthesize organo nitrile, alkyne, heterocycle, amidine. As an efficient and very mild reaction, desulfitative cross coupling is the best way to prepare high enantiopurity alpha-amino ketone and peptidyl ketone. The major part of this book describes how to develop the chemistry of palladium catalyzed N-protected peptidyl thiol ester and boronic acid cross coupling to generate peptidyl ketone with high yield and enantiopurity. Moreover, this methodology has been used as the key reaction to synthesize (-)-D-erythro-sphingosine and relative sphingolipids. In the end, the second generation of peptidyl ketone synthesis by copper catalysis is fully described in chapter 4, which represents the future of desulfitative carbon-carbon cross coupling reaction.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
http://www.lap-publishing.com/
By (author) :
Hao Yang
Number of pages:
192
Published on:
2009-09-15
Stock:
Available
Category:
Organic chemistry
Price:
8549.74 руб
Keywords:
carbon-carbon cross coupling, peptidyl ketone, Sphingosine, sphingolipid, desulfitative cross coupling, sphingosine

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