Bookcover of Regulatory Mechanisms Controlling HIV-1 Induced Immune Activation
Booktitle:

Regulatory Mechanisms Controlling HIV-1 Induced Immune Activation

A Molecular and Functional Approach

VDM Verlag Dr. Müller (2008-10-10 )

Books loader

Omni badge eligible for voucher
ISBN-13:

978-3-639-08889-2

ISBN-10:
3639088891
EAN:
9783639088892
Book language:
English
Blurb/Shorttext:
The most widely accepted theory for the massive depletion of CD4+ T cells in HIV-1 infection involves depletion of non-infected cells through immune activation. A specialized cell population, the T regulatory cells (Tregs), exists to help limit chronic inflammation by suppressing the immune activation induced by infectious diseases. We used an SIV/pigtailed macaque model of HIV-1 disease to elucidate the role of Tregs in HIV-1-induced depletion of CD4+ T cells in lymphoid tissue during the acute phase of infection. From this model, we learned that Tregs play a significant role in controlling the apoptotic loss of CD4+ T cells resulting from high levels of generalized immune activation. Using assays developed in the macaque model, we next studied the role of Tregs in elite suppressors who are HIV-1-infected individuals that maintain normal CD4+ T cell counts and control viremia without therapy. The assays developed in our laboratory should be especially useful to the future studies of both virologists and immunologists.
Publishing house:
VDM Verlag Dr. Müller
Website:
http://www.vdm-verlag.de/
By (author) :
Chase Dr. Amanda Jewell
Number of pages:
76
Published on:
2008-10-10
Stock:
Available
Category:
Microbiology
Price:
4804.51 руб
Keywords:
HIV, SIV, GALT, Virus, immune activation, elite controller, LTNP, AIDS, CD4 depletion, FOXP3

Books loader

Newsletter

Wire Transfer

  0 products in the shopping cart
Edit cart
Loading frontend
LOADING