- Natural-, Medical- , Computer Sciences, Technology
- Chemistry
- Inorganic chemistry
- HNO ADDUCTS OF HORSE MYOGLOBIN AND HUMAN HEMOGLOBIN
- Bookcover of HNO ADDUCTS OF HORSE MYOGLOBIN AND HUMAN HEMOGLOBIN
- Booktitle:
-
HNO ADDUCTS OF HORSE MYOGLOBIN AND HUMAN HEMOGLOBIN
Generation, Reactivity, Reaction Rates...
LAP LAMBERT Academic Publishing (2009-05-22 )
eligible for voucher
- ISBN-13:
978-3-8383-0158-7
- ISBN-10:
- 3838301587
- EAN:
- 9783838301587
- Book language:
- Blurb/Shorttext:
- The first chapter is a summary of recent publications about the effect of HNO in the cardiovascular system, detection of HNO in vitro, and physiological reactivity of HNO. The second chapter provides synthetic details of a newly developed method of a synthesis of HNO-Mb of high purity (> 95%). The transient absorbance studies of HNO-Mb revealed completely different results than that of other myoglobin adducts such as MbO2 and NO- Mb. Formation of the Mb-Fe(III)/HNO- geminate pair was confirmed by analyses of transient absorbance spectra at 395 nm. In the third chapter rate constants of the reaction of HNO with Mb-Fe(II), Mb- Fe(III), HNO-Mb, and HNO-Mb with oxygen and nitric oxide were determined using the computational software React for Windows. In addition to the computational method, a direct method of comparison of the rates of the reaction of HNO with proteins was developed. In the last chapter synthesis of HNO adduct of hemoglobin is reported. UV-vis, EPR, and 1H NMR spectroscopic techniques were used to identify and differentiate the hydride peaks of HNO subunits of hemoglobin.
- Publishing house:
- LAP LAMBERT Academic Publishing
- Website:
- http://www.lap-publishing.com/
- By (author) :
- Dmitry Pervitsky
- Number of pages:
- 108
- Published on:
- 2009-05-22
- Stock:
- Available
- Category:
- Inorganic chemistry
- Price:
- 4700.97 руб
- Keywords:
- Myoglobin, Hemoglobin, NO, HNO, Nitric Oxide, nitrosyl hydride, Generation, Reactivity, Kinetics, rates., hemoglobin, nitric oxide, generation, kinetics
