Bookcover of HNO ADDUCTS OF HORSE MYOGLOBIN AND HUMAN HEMOGLOBIN
Booktitle:

HNO ADDUCTS OF HORSE MYOGLOBIN AND HUMAN HEMOGLOBIN

Generation, Reactivity, Reaction Rates...

LAP LAMBERT Academic Publishing (2009-05-22 )

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ISBN-13:

978-3-8383-0158-7

ISBN-10:
3838301587
EAN:
9783838301587
Book language:
English
Blurb/Shorttext:
The first chapter is a summary of recent publications about the effect of HNO in the cardiovascular system, detection of HNO in vitro, and physiological reactivity of HNO. The second chapter provides synthetic details of a newly developed method of a synthesis of HNO-Mb of high purity (> 95%). The transient absorbance studies of HNO-Mb revealed completely different results than that of other myoglobin adducts such as MbO2 and NO- Mb. Formation of the Mb-Fe(III)/HNO- geminate pair was confirmed by analyses of transient absorbance spectra at 395 nm. In the third chapter rate constants of the reaction of HNO with Mb-Fe(II), Mb- Fe(III), HNO-Mb, and HNO-Mb with oxygen and nitric oxide were determined using the computational software React for Windows. In addition to the computational method, a direct method of comparison of the rates of the reaction of HNO with proteins was developed. In the last chapter synthesis of HNO adduct of hemoglobin is reported. UV-vis, EPR, and 1H NMR spectroscopic techniques were used to identify and differentiate the hydride peaks of HNO subunits of hemoglobin.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
http://www.lap-publishing.com/
By (author) :
Dmitry Pervitsky
Number of pages:
108
Published on:
2009-05-22
Stock:
Available
Category:
Inorganic chemistry
Price:
4700.97 руб
Keywords:
Myoglobin, Hemoglobin, NO, HNO, Nitric Oxide, nitrosyl hydride, Generation, Reactivity, Kinetics, rates., hemoglobin, nitric oxide, generation, kinetics

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