Bookcover of Galectin-1 and apoptosis
Booktitle:

Galectin-1 and apoptosis

Induction of apoptosis in galectin-1 stimulated Jurkat T lymphocytes

LAP LAMBERT Academic Publishing (2010-05-07 )

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ISBN-13:

978-3-8383-3483-7

ISBN-10:
3838334833
EAN:
9783838334837
Book language:
English
Blurb/Shorttext:
Galectin-1 (gal-1), a member of the family of beta galactoside binding proteins, participates in several biological processes such as immunomodulation, cell adhesion, regulation of cell growth and apoptosis. The aim of this study was to investigate whether gal-1 the mechanisms of T cell activation on the level of signal transduction induced by galectin-1 (gal-1) having immunosuppressive activity. Gal-1 recognizes and cross-links appropriate glycoepitopes (Galβ1- 4GlcNAc- sequences) on T cell activation markers (CD2, CD3, CD45) and stimulates in parallel several interacting signalling pathways leading to suppression of the expression of Th1 cytokines and to apoptosis in thymocytes, activated T- cells, and in leukemic T cell lines. In cellular models by applying cell- and glycobiological methods we have focused on gal-1 induced or suppressed signalling pathways involved in inhibition of a processive immune response of antigen-stimulated T lymphocytes. In this way, by depletion of activated T cells gal-1 is a negative regulator of the immune response. Therefore, the mechanism of gal-1 induced T cell apoptosis is of special interest.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
http://www.lap-publishing.com/
By (author) :
Ehab Aboueladab
Number of pages:
144
Published on:
2010-05-07
Stock:
Available
Category:
Biochemistry, biophysics
Price:
5229.65 руб
Keywords:
Galectin-1, inhibition of N-glycan, Jurkat T lymphocytes, Jun N-terminal kinase, p38 MAPK, poly (ADP-ribose) polymerase, procaspase, Bcl-2 expression

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