- Natural-, Medical- , Computer Sciences, Technology
- Biology
- Biochemistry, biophysics
- Development of Novel Peptide Inhibitors to BAG-1
- Bookcover of Development of Novel Peptide Inhibitors to BAG-1
- Booktitle:
-
Development of Novel Peptide Inhibitors to BAG-1
Applications of Peptidyl-Biomimetics to reduce and eliminate tumor resistance to chemotherapy
LAP LAMBERT Academic Publishing (2014-10-14 )
eligible for voucher
- ISBN-13:
978-3-659-61692-1
- ISBN-10:
- 3659616923
- EAN:
- 9783659616921
- Book language:
- Blurb/Shorttext:
- One of the most challenging aspects of treating tumors with chemotherapy is that the tumors can develop a resistance to the chemotherapy and survive while the rest of the healthy, non-cancerous cells perish. Higher doses of chemotherapy deliver fewer positive results and at the expense of greater side effects. The purpose of this book is to identify and exploit a weakness at the molecular level of the anti-apoptotic pathway utilized by cancer cells to turn off the "triggered cell death" mechanism of apoptosis and survive chemotherapy. We specifically target the interaction between the anti-apoptotic protein Bcl-2 Associated Athanogene (BAG-1) and the 70-kilodalton Heat Shock Protein (HSP-70) that is suspected of driving the chemotherapeutic resistance, and seek to disrupt that interaction via peptidyl-biomimetically engineered peptides that are predicted via an in-house computational software named "Contact" and experimentally verified via Biacore (c) binding assays. The program "Contact" is now available for free download at http://www.engineering.vcu.edu/proteinengineering/
- Publishing house:
- LAP LAMBERT Academic Publishing
- Website:
- http://www.lap-publishing.com/
- By (author) :
- Jonathan Brunn
- Number of pages:
- 92
- Published on:
- 2014-10-14
- Stock:
- Available
- Category:
- Biochemistry, biophysics
- Price:
- 6901.91 руб
- Keywords:
- BAG-1 HSP-70 peptide inhibitor cancer tumor suppression peptidyl-biomimetics
