Bookcover of CD4 T Helper Cells in ACAID and Corneal Immune Privilege
Booktitle:

CD4 T Helper Cells in ACAID and Corneal Immune Privilege

A perspective from IL-17A

LAP LAMBERT Academic Publishing (2011-12-28 )

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ISBN-13:

978-3-8473-2641-0

ISBN-10:
3847326414
EAN:
9783847326410
Book language:
English
Blurb/Shorttext:
Corneal transplantation is the oldest and most common form of solid organ transplantation. In uncomplicated first-time cases, corneal allografts enjoy a success rate of up to 90% even though the transplants are performed without HLA matching or the use of systemic immunosuppressive drugs. Yet, every year in the United States, nearly 8000 patients reject their transplanted corneas at a cost of a quarter of a billion dollars. In order to better understand the immune mechanisms underlying graft failure, my research examined the role of CD4+ Thelper lymphocytes in the process, notably the recently described Thelper 17 subset. Surprisingly, blockade of the effector CD4+ Thelper subsets, by depletion of their inflammatory cytokines, exacerbated corneal allograft rejection in a murine model of keratoplasty. Our investigations uncover novel protective roles for the cytokines IL-17A and IFN-γ, and describe how their interaction with T regulatory cells is required for anterior chamber associated immune deviation and corneal immune privilege.
Publishing house:
LAP LAMBERT Academic Publishing
Website:
http://www.lap-publishing.com/
By (author) :
Khrishen Cunnusamy
Number of pages:
156
Published on:
2011-12-28
Stock:
Available
Category:
Medicine
Price:
5254.34 руб
Keywords:
Eye, Transplantation, Th17, Cornea, ACAID, Immune Privilege, IL-17

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